Inflammation is the body’s natural defense against injury or infection, but when it never shuts off, it becomes damaging. In functional medicine, conditions like Chronic Inflammatory Response Syndrome (CIRS) are understood as the result of the immune system staying in constant overdrive, often triggered by environmental toxins like mold or biotoxins. This leaves patients with a wide range of symptoms that are difficult to explain or diagnose in traditional settings.
Dr. David M. Creech is a board-certified physician in Wilmington, Delaware. He aims to uncover the root causes of persistent inflammation and create targeted treatment strategies to restore balance at his practice, Delaware Functional Medicine and Longevity.

What Is Chronic Inflammatory Response Syndrome?
CIRS develops when the immune system reacts abnormally to biotoxin exposure. Instead of calming down after the initial response, inflammation continues, leading to ongoing dysfunction. Triggers may include:
- Mold or mycotoxin exposure
- Tick-borne illnesses such as Lyme disease
- Water-damaged buildings
- Other environmental biotoxins
This constant immune activation can affect the brain, lungs, joints, and overall energy levels.
Symptoms Linked to CIRS
Because inflammation is systemic, CIRS can mimic many other conditions. Patients may experience:
- Brain fog, memory problems, or poor concentration
- Shortness of breath or chronic sinus issues
- Joint pain, muscle aches, or weakness
- Persistent fatigue and low stamina
- Sensitivity to light, sound, or temperature
- Sleep disturbances and mood changes
Without proper evaluation, these symptoms are often misattributed to other conditions.
Who Should Consider CIRS Evaluation?
You may benefit from functional medicine testing for CIRS if you:
- Live or work in a water-damaged or mold-contaminated building
- Have unresolved symptoms after Lyme disease or similar infections
- Experience multiple unexplained symptoms across different systems
- Have seen multiple providers without a clear diagnosis
- Want a comprehensive, root-cause approach to chronic inflammation
How Functional Medicine Addresses CIRS
Dr. Creech uses advanced testing to identify immune markers and potential biotoxin exposure. Treatment plans often include:
- Removing or reducing exposure to environmental triggers
- Nutritional strategies to calm systemic inflammation
- Detoxification support for toxins contributing to immune activation
- Regular monitoring to adjust care as symptoms evolve
This approach emphasizes both immediate relief and long-term restoration of immune balance.
Why Choose Delaware Functional Medicine and Longevity?
CIRS is often misunderstood and misdiagnosed, leaving patients frustrated and without answers. At our Wilmington clinic, Dr. Creech provides the time, attention, and expertise needed to evaluate complex inflammatory conditions. His training allows him to bridge conventional medical knowledge with functional strategies that get to the root of the problem.
Patients choose Delaware Functional Medicine and Longevity because they want care that goes beyond symptom suppression. Here, CIRS is treated with the seriousness it deserves, using advanced diagnostics and physician-led strategies.
Take Control of Chronic Inflammation
If inflammation has taken over your life, there are answers. Delaware Functional Medicine and Longevity in Wilmington, Delaware, provides comprehensive care for CIRS and other chronic inflammatory conditions. Call (302) 599-9542 to speak with our team and schedule an appointment.